C. Jacob publications

(download as a pdf)



Vaquié A, Sauvain A, Duman M, Nocera G, Egger B, Meyenhofer F, Falquet L, Bartesaghi L, Chrast R, Lamy CM, Bang S, Lee S-R, Jeon NL, Ruff S, Jacob C (2019). Injured axons instruct Schwann cells to build constricting actin spheres to accelerate axonal disintegration. Cell Reports 27: 3152–3166. Cover




Vaquié A, Sauvain A, Jacob C (2018). Modeling PNS and CNS myelination using microfluidic chambers, in Myelin: Methods and Protocols, Springer Protocols. Methods in Molecular Biology 1791: 157–168.




Jacob C (2017). Chromatin-remodeling enzymes in control of Schwann cell development, maintenance and plasticity. Current Opinion in Neurobiology 47: 24-30. (link)

Jacob C (2017). Accélérer la repousse axonale en retardant la réponse des histone déacétylases après une lésion nerveuse. HAUSARZT PRAXIS medizinonline 12(4): 8–9.

Brügger V, Duman M, Bochud M, Münger E, Heller M, Ruff S & Jacob C (2017). Delaying histone deacetylase early response to injury accelerates conversion into repair Schwann cells and nerve regeneration. Nature Communications 8:14272 (online doi:10.1038/ncomms14272) (link




Mishra S, Khaddaj R, Cottier S, Stradalova V, Jacob C & Schneiter R (2016). Mature lipid droplets are accessible to ER luminal proteins. Journal Cell Science 129: 3803-3815. (online doi: 10.1242/jcs.189191) (link)




Brügger V, Engler S, Pereira JA, Ruff S, Horn M, Welzl H, Münger E, Vaquié A, Sidiropoulos PNM, Egger B, Yotovski P, Filgueira L, Somandin C, Lühmann TC, D’Antonio M, Yamaguchi T, Matthias P, Suter U & Jacob C (2015). HDAC1/2-dependent P0 expression maintains paranodal and nodal integrity independently of myelin stability through interactions with neurofascins. PLOS Biology 13(9): e1002258. doi:10.1371/journal.pbio.1002258. (pdf)
(Featured in Synopsis of PLoS Biology 13:e1002259)

Jacob C (2015). Transcriptional control of neural crest specification into peripheral glia. Glia 63: 1883-1896.




Jacob C, Lötscher P, Engler S, Baggiolini A, Varum Tavares S, Brügger V, John N, Büchmann-Møller S, Snider PL, Conway SJ, Yamaguchi T, Matthias P, Sommer L, Mantei N & Suter U (2014). HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia. Journal of Neuroscience 34(17):6112-6122; doi:10.1523/JNEUROSCI.5212-13.2014. (pdf)




Jacob C (2013). Mechanisms that control Schwann cell plasticity after a PNS lesion. e-News for Somatosensory Rehabilitation.10(2):59-62. (pdf)  

Pattaroni C & Jacob C (2013) Histone methylation in the nervous system: functions and dysfunctions. Molecular Neurobiology 47: 740-756 (Epub 2012 Nov 17) [pdf]   




Jacob C, Lebrun-Julien F & Suter U (2011). How histone deacetylases control myelination. Molecular Neurobiology 44: 303-312.

Jacob C, Christen CN, Pereira J, Somandin C, Baggiolini A, Lötscher P, Özçelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P & Suter U (2011). Schwann cell survival and myelination are critically dependent on HDAC1 and HDAC2 function. Nature Neuroscience 14: 429-436 (Featured in News and Views of Nature Neuroscience 14: 401-403).




Cotter L, Özçelik M, Jacob C, Pereira JA, Locher V, Baumann R, Relvas JB, Suter U & Tricaud N (2010). Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science 328: 1415-1418.

Pereira JA, Baumann R, Norrmén C, Somandin C, Miehe M, Jacob C, Lühmann T, Hall-Bozic H, Mantei N, Meijer D & Suter U (2010). Dicer in Schwann cells is required for myelination and axonal integrity. Journal of Neuroscience 30: 6763-6775.

Ozçelik M, Cotter L, Jacob C, Pereira J, Relvas J, Suter U & Tricaud N (2010). Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. Journal of Neuroscience 30: 4120-4131.




Jacob C, Grabner H, Atanasoski S & Suter U (2008). Expression and localization of Ski determine cell type-specific effects of TGFbeta on the cell cycle. Journal of Cell Biology 182: 519-530.




Jacob C & Bunnett N (2006). Transmembrane signaling by G protein-coupled receptors. Chapter 3 In "Physiology of the gastrointestinal tract" 4th Edition (LR Johson), Vol 1, pp 63-90 Academic Press.




Jacob C, Yang P, Darmoul D, Amadesi S, Cotrell GS, Saito T, Singh P, Grady E F, Perdue M & Bunnett NW (2005) Mast cells control paracellular permeability of the intestine: role of protease-activated receptor 2 and beta-arrestins. Journal of Biological Chemistry 280: 31936-31948.

Jacob C, Cotrell GS, Schmidlin F, Grady EF & Bunnett NW (2005). The E3-ubiquitin ligase c-Cbl regulates protease-activated receptor 2 (PAR2). Journal of Biological Chemistry 280: 16076-16087.




Jacob C, Szilagyi C, Allen JM, Bertrand C & Lagente V (2004). Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism. British Journal of Pharmacology 143: 257-268.        

Martin-Chouly C, Astier A, Jacob C, Pruniaux M-P, Bertrand C & Lagente V (2004). Modulation of MMP-2 production from human lung fibroblasts by selective phosphodiesterase type-4 inhibitors. Life Sciences 75: 823-840.




Jacob C, Leport M, Szilagyi C, Allen JM, Bertrand C & Lagente V (2002). DMSO-treated HL60 cells: a model of neutrophil-like cells mainly expressing PDE4B subtype. International Immunopharmacology 2: 1647-1656.

Jacob C, Martin-Chouly C & Lagente V (2002). Type 4 phosphodiesterases dependent pathways: Role in inflammatory processes. Therapie 57: 163-168.



Inventors: Jacob Claire and Szilagyi Corinne
Non-recombinant cell lines capable of expressing a single PDE4 subtype and their use for the screening of PDE4 subtype-specific modulators
Patent n° 01401026.8-1212, registered in Europe.