Salentinig Research Group has recently published a new article in the Journal of Colloid and Interface Science, entitled "Human antimicrobial peptide inactivation mechanism of enveloped viruses"  in collaboration with their colleagues from Nanyang Technological University Singapore and ISIS at the Rutherford Appleton Laboratory in Oxford, UK.

Congratulations to Prof. Stefan Salentinig, and Eliane Haenni, Samuel Watts, and Rafael Vasconcelos de Melo Freire from his research group as well as Gregory N. Smith and Najet Mahmoudi from Rutherford Appleton Laboratory and to Sierin Lim from NTU Singapore!

For more information and to read the article: https://www.sciencedirect.com/science/article/pii/S0021979723021744

Abstract

Hypothesis

Enveloped viruses are pivotal in causing various illnesses, including influenza and COVID-19. The antimicrobial peptide LL-37, a critical part of the human innate immune system, exhibits potential as an antiviral agent capable of thwarting these viral threats. Its mode of action involves versatile and non-specific interactions that culminate in dismantling the viral envelope, ultimately rendering the viruses inert. However, the exact mechanism of action is not yet understood.