Alzheimer's disease reseach

Since 2017, Prof Annoni together with Dr. Alberi Auber and the HFR memory clinic are running a project on salivary diagnostic for early diagnosis of Alzheimer’s disease. These clinical studies investigate the host-pathogen interaction that may underlie the inflammatory etiology of Alzheimer’s disease (AD) and its long asymptomatic progression. Our previous work has revealed that the microbial and inflammatory profiling of saliva can be used as a diagnostic classifier of dementia staging. Our research also shows that whole unstimulated saliva shares about a third of the proteome with the cerebrospinal fluid, making it suitable to detect non-invasively neural-derived protein that may reflect impinging neuronal deficits. The overarching aim of this research is to identify salivary fingerprints that are predictive of dementia conversion and can serve to implement preventive strategies in the adult population.

In Fall 2019, the fruitful collaboration between Prof. Annoni and Dr. Alberi Auber and their dedication to AD research has served as the foundation for a National Task Force for Dementia for more awareness in the civil society and increased federal funding in this field.