PER 09 - 0.116
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Investigations of Information Processing and Stress Reactions in Psychiatric Disorders
Participants of a group therapy program aiming to improve coping with professional stress will be invited to participate in this study. After assessment of general psychopathology, participants will undergo 3 EEG, NIRS (near infrared spectroscopy) and electrophysiology recording sessions. Reactivity towards emotional pictures (International Affective Picture System) as well as script driven imagery in relation to a neutral, a relaxing and an individual stressful audio-script will be recorded. In addition, cortisol saliva swabs will be collected before and after these exposures.
The data from 40 individuals suffering from work-related stress will be compared to the data from 50 controls.
Brain activity differs between psychotic patients and healthy controls in the responder condition of Ultimatum Game (UG) task, confirming more emotional involvement in this condition. Furthermore, we also found differences in posterior EEG channels in psychotic patients who produce more false memories in Deese-Roediger-McDermott (DRM) task. Both results will help us to elaborate new rehabilitation strategies for psychotic patients.
Variations due to task difficulty and to time course for the P2, P3a and P3b ERP components discriminate normal subjects from psychiatric patients. With a new method of ERP data analysis, we confirmed the clinical importance of this approach.
The MBSR group program aims at developing several specific capacities: directed attention, self-regulation of attention and acceptance of one’s own experiences. Its therapeutic effect has been shown for reducing stress reactions, chronic pain and several psychiatric disorders. Its common mode of action may be an impact on auto-regulation of attention and emotions. In this study, we combine subjective evaluation with neurophysiological measures.
Abnormalities in delta and gamma oscillations are related to the demands of the WM. Compared with controls, FEP patients displayed phase differences of oscillation cycles.