Rouiller Group

Laboratory of neurophysiology of action and hearing

"Ce qui est commun à l'art et à la science ? La création,
voir la démesure, car c'est elle qui caractérise la créativité."

Main lines of research

  • Motor system

    Based on the plasticity of the nervous system, a certain degree of spontaneous functional recovery may take place post-lesion. The goal of our work in non-human primates is first to elucidate mechanisms involved in such spontaneous functional recovery following spinal cord lesion, motor cortex lesion or Parkinson disease. Second, in the context of translational medicine, different promising therapeutic strategies are tested with the goal to enhance the spontaneous functional recovery:

    Neutralization of neurite growth inhibitors: anti-Nogo-A antibody treatment.

    Cellular therapy: see  "autotransplantation" for details

    External collaborations:

    Prof. Martin Schwab (University of Zürich), Dr. Jocelyne Bloch (University of Lausanne), Dr. Jean-François Brunet(University of Lausanne), Dr. Anis Mir (Novartis), Prof. Stuart Baker (University of Newcastle, UK), Prof. H.M. Hougewood (Fribourg Hostpital), Prof. G. Innocenti (EPFL lausanne)

    Recent key publications:

    Lanz ., Moret V., R. Ambett., C. Cappe., E.M. Rouiller., G. Loquet. (2017). Distant heterotopic callosal connections to premotor cortex in non-human primates. Frontiers in Human Neurosciences 344: 56-66 [pdf]

    Fregosi M., Contestabile A., Hamadjida A., Rouiller E.M. (2017). Corticobulbar projections from distinct motor cortical areas to the reticular formation in macaque monkeys. Europ. J. Neuroscience 45: 1379-1395.

    Savidan J., Kaeser M., Belhaij-Saif A., Schmidlin E., Rouiller E.M. (2017) Role of primary motor cortex in the control of manual dexterity assessed via a sequential bilateral lesion in the adult macaque monkey: a case study. Neuroscience 357: 303-324.

    Fregosi M., Rouiller E.M. (2017). Ipsilateral corticotectal projections from the primary, premotor and supplementary motor cortical areas in adult macaque monkeys: a quantitative anterograde tracing study. Europ. J. Neuroscience 46: 2406-2415.

    Badoud S.*, Borgognon S.*, Cottet J.*, Chatagny P., Moret V., Fregosi M., Kaeser M., Fortis E., Schmidlin E., Bloch J., Brunet J.F., Rouiller E.M. (2016) Effects of dorsolateral prefrontal cortex lesion on motor habit and performance assessed with manual grasping and control of force in macaque monkeys. Brain Struct. Funct. 222:1193-1206 [pdf]                        

    Innocenti G.M., Dyrby T.B., Andersen K.W., Rouiller E.M., Caminiti R. (2016) The Crossed Projection to the Striatum in Two Species of Monkey and in Humans: Behavioral and Evolutionary Significance. Cereb Cortex. 2017 Jun 1;27(6):3217-3230

    Kaeser M.*, Chatagny P.*, Gindrat A.D., Savidan J., Badoud S., Fregosi M., Moret V., Roulin C., Schmidlin E.& and Rouiller E.M.& (2014) Variability of manual dexterity performance in non-human primates (Macaca fascicularis). International Journal of Comparative Psychology 27 (2): 295-325. 

    Gindrat A.D.*, Chytiris M.*, Balerna M.*, Rouiller E.M. and Ghosh A. (2015) L’utilisation de smartphones façonne le traitement cortical de l’information sensorielle tactile provenant de l’extrémité des doigts. Med. Sci. (Paris) 31: 363-366 [pdf]  [pdf english]

    Chatagny P.*, Badoud S.*, Kaeser M., Gindrat A.D., Savidan J., Fregosi M., Moret V., Roulin C., Schmidlin E., Rouiller E.M. (2013). Distinction between hand dominance and hand preference in primates: a behavioral investigation of manual dexterity in nonhuman primates (macaques) and human subjects. Brain and Behavior 3 (5): 575-595. [pdf]

    Kaeser M., Wannier T., Brunet J.F., Wyss A., Bloch J. and Rouiller E.M. (2013) Representation of motor habit in a sequence of repetitive reach and grasp movements performed by macaque monkeys: evidence for a contribution of the dorsolateral prefrontal cortex. Cortex 49: 1404-1419.

    Wyss A.F.*, Hamadjida A.*, Savidan J.*, Liu Y., Bashir S., Mir A., Schwab M.E., Rouiller E.M.&, Belhaj-Saif A.& (2013) Long-term motor cortical map changes following unilateral lesion of the hand representation in the motor cortex in macaque monkeys showing functional recovery of hand functions. Rest. Neurol. and Neurosci. 31: 733-760. [pdf]

    Hoogewoud F.*, Hamadjida A.*, Wyss A.F., Mir A., Schwab M.E., Belhaj-Saif A., Rouiller E.M. (2013). Comparison of functional recovery of manual dexterity after unilateral spinal cord lesion or motor cortex lesion in adult macaque monkeys. Front. Neurol. 2013, 4: 101. doi: 10.3389/fneur.2013.0010 [pdf]

    Hamadjida A., Wyss A.F., Mir A., Schwab M.E., Belhaj-Saif A.&Rouiller E.M.& (2012) Influence of anti-Nogo-A antibody treatment on the reorganization of callosal connectivity of the premotor cortical areas following unilateral lesion of primary motor cortex (M1) in adult macaque monkeys. Exp. Brain Res. 223: 321-340. [pdf]                                                                    

    Beaud M.L., Rouiller E.M., Bloch J., Mir A., Schwab M.E., Wannier T., Schmidlin E. (2012). Invasion of lesion territory by regenerating fibers after spinal cord injury in adult macaque monkeys. Neurosci. 227: 271-282. [pdf]

    Jörn Peuser*, Abderraouf Belhaj-Saif*, Adjia Hamadjida, Eric Schmidlin, Anne-Dominique Gindrat, Andreas Charles Völker, Pavel
    Zakharov, Henri-Marcel Hoogewoud, Eric M. Rouiller&, Frank Scheffold& (2011) Follow-up of cortical activity and structure after lesion with laser speckle imaging (LSI) and magnetic resonance imaging (MRI) in non-human primates. J. Biomed. Optics 16: doi:10.1117/1.3625287. [pdf]

    Kaeser M*., Brunet J.F*., Wyss A.F., Belhaj-Saïf A., Liu Y., Rouiller E.M.+ and Bloch J.(2011) Autologous adult cortical cell implantation enhanced functional recovery of manual dexterity after unilateral lesion of motor cortex in non-human primates. Neurosurgery 68: 1405-1417. [pdf]

    Bashir S.*, Kaeser M.*, Wyss A.F.*, Hamadjida A.*, Liu Y., Bloch J., Brunet J.F., Belhaj-Saif A., and Rouiller E.M.(2011) Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys. Brain Structure and Function 217: 63-79. [pdf]                  

    Bloch J., Kaeser M., Sadeghi Y., Rouiller E.M., Redmond D.E.,Jr. and Brunet J.F. (2011) Doublecortin-positive cells in the adult primate cerebral cortex and possible role in brain plasticity and development. J. Comp. Neurol. 519: 775-789. [pdf]

    Kaeser M., Wyss A.F., Bashir S., Hamadjida A., Liu Y., Bloch J., Brunet J.F., Belhaj-Saif A., Rouiller E.M. (2010) Effects of unilateral motor cortex lesion on ipsilesional hand’s reach and grasp performances in monkeys: relationship with recovery in the contralesional hand. J. Neurophysiol. 103: 1630-1645. [pdf]

    Freund, P.*, Schmidlin, E.*, Wannier T.*, Bloch J., Mir A., Schwab M.E. and Rouiller E.M. (2009) Anti-Nogo-A antibody treatment promotes recovery of manual dexterity after unilateral cervical lesion in adult primates: re-examination and extension  of behavioral data. Europ. J. Neurosci. 29: 983-996. [pdf]

    Courtine G., Bunge M.B., Fawcett J.W., Grossman R.G., Kaas J.H., Lemon R., Maier I., Martin J.H., Nudo R.J., Ramon-Cueto A., Rouiller E.M., Schnell L., Wannier T., Schwab M.E. and Edgerton V.R. (2007) Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? Nat. Med. 13(5): 561-566.

     Freund P.+, Wannier T.+, Schmidlin E.+, Bloch J., Mir A., Schwab M.E. and Rouiller E.M. (2007) Anti-Nogo-A antibody treatment enhances sprouting of corticospinal (CS) axons rostral to an unilateral cervical cord lesion in adult macaque monkeys. J. Comp. Neurol., 502: 644-659.

    * Equal first authorship
    + Equal senior authorship
    & Equal senior authorship

  • Multisensory integration

    Multisensory processes are widespread in the brain and integrate information from more senses than once thought. However, the underlying mechanisms contributing to organization for action are still unclear. Therefore investigating impaired functions like (1), (2) and (3) is one of the possible ways to highlight key steps in multisensory processing. Along with such interests, our research projects examine also how attention modulates multisensory processes and how it is influenced by training in a rehabilitative perspective.


    Recent key publications:

    Lanz ., Moret V., R. Ambett., C. Cappe., E.M. Rouiller., G. Loquet. (2017). Distant heterotopic callosal connections to premotor cortex in non-human primates. Frontiers in Human Neurosciences 344: 56-66 [Abstract] [pdf]

    Lanz F., Moret V., Rouiller E.M., Loquet G.(2013). Multisensory integration in non-human primates during a sensory-motor task. Frontiers in Human Neurosciences Nov 20;7: 799. [Abstract]

    Cappe C., Rouiller E.M., Barone P. (2012). Cortical and Thalamic Pathways for Multisensory and Sensorimotor Interplay. In: Murray M.M. and Wallace M.T. (eds), The neural bases of multisensory processes. Boca Raton (FL), CRC Press, Chapter 2, http://www.ncbi.nlm.nih.gov/books/NBK92866/ [Abstract]

    Cappe, C., Rouiller E.M. and Barone P. (2009) Multisensory anatomical pathways. Hearing Res. 258: 28-36. [Abstract]