Jens Volker Stein
Büro PER 09 - 1.120
+41 26 300 8602
The adaptive immune system protects us from harmful microbial infections and cancer, while providing life-long immunity after vaccination. To accomplish this extraordinary feat, cellular components of the immune system, T and B cells, continuously interact with antigen-presenting cells (APCs) in lymphoid organs. A well-studied example are naïve T cells interactions with dendritic cells (DCs), the most powerful APCs for this subset. This leads to T cell activation, division and invasion of infected organs and contributes decisively to pathogen or tumor elimination. While the general principle of such adaptive immune responses is well established, little is known on how this remarkable process unfolds in the context of tissue architecture and cellular dynamics.
Our laboratory is using imaging-based methods, in combination with more conventional methods such as multicolor flow cytometry and functional in vitro assays, to “shed light” on the molecular and cellular processes that govern adaptive immune responses. We follow three lines of investigation: