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  • Post-doctoral position in Microbiology

    Emerging antibiotic resistance is being recognized as a crosscutting threat to global health. Multidrug resistance is observed currently mostly in Gram-negative bacteria. It is dominated by the emergence of carbapenemase producers and to a certain extend to resistance to polymyxins and fosfomycin. Carbapenemases are bacterial ?-lactamases that hydrolyze almost all broad- spectrum ?-lactams, including the carbapenems (i.e. imipenem). Curtailing their spread requires a better understanding of the plasticity of carbapenemase genes at different levels, from bacterial species constituting their reservoir to their final host, once acquired. Polymyxins and Fosfomycin are now considered as last resort antibiotics for treating infections due to multidrug resistant bacterial infections.

    To join the research group of Prof. Nordmann at the Section of Medicine of the University of Fribourg (Switzerland), we offer a Post-doctoral position in Microbiology to work in a clinically-relevant projects at the interface of genetics, biochemistry and medical microbiology.

    Your project: You will investigate in particular the mobilization processes of resistance genes from their natural reservoirs to their targets and participate to decipher any novel antibiotic resistance mechanisms including to fosfomycin. You will also contribute to the discovery of novel resistance genes that are spreading worldwide, to develop novel rapid diagnostic tests for antibiotic resistance detection and evaluate/develop novel antibiotics .

    You have: a PhD degree in Life Sciences or/and MD/Pharm D degree in Medicine/Pharmacy and a strong interest in studying antibiotic resistance in the context of molecular microbiologyO/and protein analyses

    We offer: Cutting-edge research projects, excellent research facilities and full funding and the possibility to join a highly competitive group.

    The position would start best October 1, 2019

    Please send your complete documentation (CV, publication list..) to Prof. Patrice Nordmann at: patrice.nordmann@unifr.ch.

  • PhD position in renal oxygen physiology

    The group of Prof. David Hoogewijs at the department of Endocrinology, Metabolism and Cardiovascular Systems from the University of Fribourg, Switzerland, invites applications from motivated and engaged young scientist to join the team and to conduct a PhD in the domain of oxygen physiology and its possible link to renal (patho)physiology.

    Application deadline: 30th June 2019.

    For further information, details, and application, please refer to:

    PhD position in renal oxygen physiology

  • PhD position in Endocrinology

    Project

    Novel approaches to study human sex development and its defects.

    A PhD position is open in Prof. Anna Lauber-Biason’s lab, at Division of Endocrinology of the Section of Medicine of the University of Fribourg, Switzerland, to study the molecular mechanisms of sex development in humans.

    Our group is part of the Department of Endocrinology, Metabolism and Cardiovascular System that offers a multicultural and diverse environment.

    Objective

    The main objective of the work is the elucidation of the molecular basis of human sex development to better define phenotypes and therapies of its complex defects.

    Goals 

    1. Gain new insights in sex differentiation in humans.
    2. Create new models for understanding mechanism of disease.

    Technically, the focus of the work will be to create human male and female gonadal cells from inducible pluripotent stem cells directly from patients affected by differences of sex development to study the mechanisms that lead to disease. We will also employ standard cell and molecular biology, genetics, biochemistry, exome and RNA-sequencing, CRISP-Cas9 gene editing and mass spectrometry techniques.

    Bioinformatic analysis of next generation sequencing data and 3D-modeling is also one of our expertise.

    Ideal profile

    Applicants must hold a master degree (or equivalent) and have a strong background in biochemistry, molecular and cell biology. Previous experience in these fields as well as a broad interest in translational research will be important selection criteria as are the educational background, motivation, independence and creativity. 

    The successful candidate is expected to have good English communication and writing skills. Knowledge of German or French is of advantage.

    Ideally, the candidate should be able to come to Fribourg for a personal talk.

    Salary

    according the Swiss National Science Foundation criteria

    Begin

    01.10.2019

    Duration

    4 years

    Interested applicants should send a brief description of research interests, curriculum vitae and the names of three references to:

    Anna Lauber-Biason, M.D.

    Chair of Endocrinology
    Faculty of Science and Medicine
    Medicine Section
    University of Fribourg
    Chemin du Musée 5
    1700 Fribourg

      anna.lauber@unifr.ch

     

    The University of Fribourg is Switzerland’s only bilingual university, offering a full academic curriculum both in French and German. A number of Master programmes are taught in English and the University offers a wide range of opportunities for PhD and doctoral studies as well as international Exchange and Summer School Programmes.

    The University of Fribourg places scientific research that is closely linked to academic teaching at the heart of its activities. With an array of centres of scientific excellence as well as research programmes across the entire disciplinary spectrum, we aim to extend the frontiers of scientific knowledge to help solve mankind’s current and future challenges.