Stéréochimie organique (cours avec exercices) / Organische Stereochemie (Vorlesung mit Übungen)

  • Teaching

    Details

    Faculty Faculty of Science and Medicine
    Domain Chemistry
    Code UE-SCH.03212
    Languages French , German
    Type of lesson Lecture
    Exercise
    Level Bachelor
    Semester SA-2019

    Title

    French Stéréochimie organique (cours avec exercices)
    German Organische Stereochemie (Vorlesung mit Übungen)
    English Organic stereochemistry (lecture with exercises)

    Schedules and rooms

    Summary schedule Wednesday 10:15 - 12:00, Hebdomadaire (Autumn semester)
    Struct. of the schedule 2h par semaine durant 14 semaines
    Contact's hours
    		28

    Teaching

    Responsibles
    • Bochet Christian
    Teachers
    • Bochet Christian
    Description Principes de base de la stéréochimie: Isomérie. Types de chiralité, nomenclature, règles. Complexes octaédriques. Chiralité des complexes métalliques. Méthodes de quantification des excès stéréomériques. Méthodes de détermination de la configuration absolue. Corrélation chimique. Analyse conformationelle. Prochiralité et réactions. Bases de la synthèse stéréosélective: Stratégies en synthèse asymétrique. Induction 1,2 et 1,3. Géométrie des énolates. Auxiliaires chiraux. Réactifs chiraux. Catalyse énantiosélective. Double stéréodifférentiation. Résolution cinétique. Effets non linéaires et amplification chirale

    Basic principles in stereochemistry: Isomerism. Types of chirality, nomenclature, rules. Octahedral complexes. Chirality of metallic complexes. Quantification methods of stereomeric excesses. Determination of the absolute configuration. Chemical correlation. Conformational analysis. Prochirality and reactions. Bases of stereoselective synthesis: Strategies in asymmetric synthesis. 1,2- and 1,3-Induction. Geometry of enolates. Chiral auxiliairies. Chiral reagents. Enantioselective catalysis. Double stereodifférentiation. Kinetic resolution. Non-linear effects and chiral amplification

    Grundlagen der Stereochemie: Isomerie. Typen von Chiralität, Nomenklatur, Regeln. Oktaedrische Komplexe. Chiralität von Metallkomplexen. Quantifizierungsmethoden von Stereoisomeren-Überschuss. Bestimmung von absoluten Konfigurationen. Chemische Korrelation. Konformationsanalyse. Prochiralität und Reaktionen. Grundlagen der Stereoselektiven Synthese: Strategie in asymmetrischer Synthese. 1,2- und 1,3-Induktion. Geometrie von Enolaten. Chirale Auxiliare. Chirale Reagenzien. Enantioselektive Katalyse. Doppel-Stereodifferenzierung. Kinetische Resolution. Nicht-lineare Effekte und chirale Verstärkung
    Training objectives À l'issue de ce cours, vous devriez être capables de:

    - Identifier la relation stéréochimique entre plusieurs molécules,
    - quantifier les composants d'un mélange d'isomères,
    - déterminer la configuration absolue d'une substance à l'aide des diverses techniques connues.
    - concevoir un chemin synthétique afin d'obtenir sélectivement une substance énantio- et diastéréomériquement pure,
    - rationaliser la stéréochimie d'une réaction quelconque.

    Ziel dieser Vorlesung ist es, dass Sie fähig sein sollten :
    - das stereochemische Verhältnis zwischen mehreren Molekülen zu bestimmen
    - die Zusammensetzung eines Isomerengemisches zu quantifizieren
    - die absolute Konfiguration einer Substanz mit verschiedenen bekannten Techniken zu ermitteln
    - einen Syntheseweg zu konzipieren um selektiv eine Enantiomeren- und Diastereomeren-reine Verbindung zu erhalten
    - die Stereochemie einer beliebigen Reaktion zu rationalisieren
    Softskills No
    Off field No
    BeNeFri Yes
    Mobility Yes
    UniPop No
  • Dates and rooms
    Date Hour Type of lesson Place
    18.09.2019 10:15 - 12:00 Cours PER 10, Room 313
    25.09.2019 10:15 - 12:00 Cours PER 10, Room 313
    02.10.2019 10:15 - 12:00 Cours PER 10, Room 313
    09.10.2019 10:15 - 12:00 Cours PER 10, Room 313
    16.10.2019 10:15 - 12:00 Cours PER 10, Room 313
    23.10.2019 10:15 - 12:00 Cours PER 10, Room 313
    30.10.2019 10:15 - 12:00 Cours PER 10, Room 313
    06.11.2019 10:15 - 12:00 Cours PER 10, Room 313
    13.11.2019 10:15 - 12:00 Cours PER 10, Room 313
    20.11.2019 10:15 - 12:00 Cours PER 10, Room 313
    27.11.2019 10:15 - 12:00 Cours PER 10, Room 313
    04.12.2019 10:15 - 12:00 Cours PER 10, Room 313
    11.12.2019 10:15 - 12:00 Cours PER 10, Room 313
    18.12.2019 10:15 - 12:00 Cours PER 10, Room 313
  • Assessments methods

    Oral exam - SA-2019, Session de printemps 2020

    Assessments methods By rating
    Descriptions of Exams

    épreuve orale de 30 min

    Oral exam - SP-2020, Session d'été 2020

    Assessments methods By rating
    Descriptions of Exams

    épreuve orale de 30 min
    Comment Examen oral en ligne 30 min

    Oral exam - SP-2020, Autumn Session 2020

    Date 04.09.2020 10:20 - 11:30
    Assessments methods By rating
    Descriptions of Exams

    épreuve orale de 30 min
    Comment Examen oral en ligne 30 min

    Oral exam - SA-2020, Session d'hiver 2021

    Date 05.02.2021 11:20 - 11:50
    Assessments methods By rating
    Descriptions of Exams

    épreuve orale de 30 min
    Comment

    Examen oral en ligne 30 min 

    Oral exam - SP-2021, Session d'été 2021

    Assessments methods By rating
    Descriptions of Exams

    épreuve orale de 30 min
    Comment

    Examen ORAL en ligne 30 min (COVID-19)

    Oral exam - SP-2021, Autumn Session 2021

    Assessments methods By rating
    Descriptions of Exams

    épreuve orale de 30 min
    Comment

    Examen ORAL en ligne 30 min (COVID-19)
  • Assignment
    Valid for the following curricula:
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    Chemistry 150
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    BSc in Chemistry, Major, 2nd-3rd year > BSc in Chemistry, Major, 2nd-3rd year (from AS2022 on)
    Chemistry 30
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    Minor in Chemistry 30 > Chemistry, Minor CH-30, elective courses (from AS2022 on)
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    Minor in Chemistry 60 (D60 for TDHSE) > Chimie, Minor CHD-60 (for TDHSE), elective courses (from AS2022 on)
    Chemistry (for Biochemists) 30
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    Pre-Master-Programme in Chemistry [PRE-MA] 0
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    Prerequisite to the MSc in Chemistry > Advanced courses in Chemistry (Bachelor level)
    Pre-Master-Programme to the MSc in Bioinformatics and Computational Biology [PRE-MA]
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    Prerequisite to the MSc in Bioinformtics and Computational Biology > Advanced courses in Chemistry (Bachelor level)